Purified Anti-Mouse CX3CR1 Antibody[SA011F11] (AN010220P)
For research use only.
Conjugation: Unconjugated
APC Elab Fluor®647 Elab Fluor®700 Elab Fluor®Violet 450 FITC PE PE/Cyanine 5 PE/Elab Fluor®594 PerCP/Cyanine 5.5 Unconjugated Show More
| Alternate Names | CX3CR, Cx3cr1 |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CX3CR1 gene |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons. |
| Immunogen | Recombinant Mouse CX3CR1 protein |
| Abbre | CX3CR1 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2a, κ |
| Isotype Control | Purified Mouse IgG2a, κ Isotype Control[C1.18.4], Functional Grade |
| Applications |
FCM
|
| Cellular Localization |
Cell membrane
|
| Tissue Specificity |
Specifically expressed in subsets of leukocytes: expressed in monocytes, subsets of T-cells and natural killer (NK) cells in the circulation, dendritic cells, as well as in microglia in the central nervous system (CNS)
|
| Concentration |
≥1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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