Purified Anti-Mouse FcεRIα Antibody[MAR-1], Functional Grade (E-AB-F11880)
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For research use only.
| Alternate Names | Fcr, Fcr-5, Fc-epsilon RI-alpha, fcepsilonri, FcERI, High affinity immunoglobulin epsilon receptor subunit alpha, Fce1a, Fcer1a |
| Clone | |
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse bone marrow |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | FcεRIα is a transmembrane protein belonging to the Ig superfamily. FcεRIα forms a tetrameric complex with one β and two γ-subunits. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcεRIα, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcεRIα subunit. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Mouse FcεRIα protein |
| Abbre | FcεRIα |
| Swissprot | |
| Host | Armenian Hamster |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Armenian Hamster IgG |
| Isotype Control | Purified Armenian Hamster IgG Isotype Control[PIP], Functional Grade |
| Applications |
FCM
|
| Cellular Localization |
Cell membrane
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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