Purified Anti-Mouse IL-10 Antibody[JES5-16E3] (E-AB-F1197A)
![Purified Anti-Mouse IL-10 Antibody[JES5-16E3] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
| Alternate Names | Interleukin, IL-, CSIF, If2a, Il-10, IL10A, TGIF, Interleukin-10, IL10, Cytokine synthesis inhibitory factor, N/A, CSIF, If2a, Il-10 |
| Clone No | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse IL-10 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. |
| Immunogen | Recombinant Mouse IL-10 protein |
| Abbre | IL-10 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2b,κ |
| Applications |
FCM
|
| Cellular Localization |
Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Other Formats
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APC
Elab Fluor®488
Elab Fluor®647
Elab Fluor®700
FITC
None (AF/LE)
PE
Unconjugated
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