RAD50 Polyclonal Antibody (E-AB-12632)
For research use only.
| Verified Samples |
Verified Samples in WB: 293T, Hela, K562, NIH/3T3, RAW264.7 Verified Samples in IHC: Human colon cancer, Human gastric cancer |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human RAD50 |
| Abbre | RAD50 |
| Synonyms | DNA repair protein RAD50, Mrell, NBSLD, RAD50, RAD50 2, RAD50 PEN, RAD50 homolog, RAD50 homolog (S cerevisiae), RAD502, Rad 50, Rad50l, S. cerevisiae, Truncated RAD50 protein, hRAD50, homolog of, hsRAD50, rad50 |
| Swissprot | |
| Calculated MW | 154 kDa |
| Cellular Localization | Nucleus. Chromosome>telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
Other Clones
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Other Formats
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Unconjugated
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