Recombinant AMPKβ1 Monoclonal Antibody (AN301259L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human colon |
| Dilution | IHC 1:100-1:500 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human AMPKβ1 protein |
| Abbre | AMPKβ1 |
| Synonyms | 5'-AMP-activated protein kinase subunit beta, PRKAB, PRKAB1, AMPK, HAMPKb, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit beta-1, AMPK, HAMPKb, AMPKβ1 |
| Swissprot | |
| Cellular Localization | Nucleus, nucleoplasm, cytosol, nucleotide-activated protein kinase complex. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Cardiovascular, Cancer, Metabolism |
| Clone No. | 5H6 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. |
Other Clones
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Unconjugated
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