Recombinant Apolipoprotein H/APOH Monoclonal Antibody (AN300392P)
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For research use only.
| Verified Samples | Verified Samples in IHC:paraffin-embedded human liver |
| Dilution | WB 1:1000, IHC-P 1:200-1:500, ICC/IF 1:100, FC 1:200-1:500, IP 1:20-1:50 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human APOH protein |
| Abbre | APOH |
| Synonyms | B2G, B2GP, Beta-2-Glycoprotein, APOH B2G, APOH, B2G1, B2GP1, BG, Activated Protein C-Binding Protein, Anticardiolipin Cofactor, APC inhibitor, Apo-H, Apolipoprotein H, B2GPIBeta(2)GPI, Beta-2-Glycoprotein 1, Beta-2-Glycoprotein I, APOH B2G1, Activated protein C binding protein, apolipoprotein H (beta-2-glycoprotein I), B2GPI, Beta 2 glycoprotein I, Beta 2 glycoprotein I precursor, Beta(2) GPI, Beta(2)GPI, beta-2, Glycoprotein 1, Glycoprotein I, OTTMUSP00000003033 |
| Swissprot | |
| Calculated MW | 38 kDa |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Affinity Purification |
| Research Areas | Cardiovascular, Signal Transduction, Metabolism |
| Clone | B318 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019] |
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