Recombinant BRD4 Monoclonal Antibody (AN301189L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Rat kidney |
| Dilution | IHC 1:100-1:200, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200, |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human BRD4 protein |
| Abbre | BRD4 |
| Synonyms | BRD, HUNK, bromodomain containing, HUNK1bromodomain-containing protein, BRD4, CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4, HUNK1bromodomain-containing protein 4, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, bromodomain containing protein 4, Bromodomain-containing protein 4, chromosome associated protein, Mitotic chromosome-associated protein, Protein HUNK1, BRD4 |
| Swissprot | |
| Cellular Localization | Nucleus, Chromosome, Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localizes to meiotic chromosomes (PubMed:21890894, PubMed:16109376), Chromosome. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Epigenetics and Nuclear Signaling, Cancer |
| Clone No. | B948 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. |
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