Recombinant CD33 Monoclonal Antibody (AN301475L)

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	100μL	$ 380.00	- +
	50μL	$ 249.00	- +

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Verified Samples	Verified Samples in IHC: Human lymphoma, Human spleen
Dilution	IHC 1:200-1:1000
Isotype	IgG, κ
Host	Rabbit
Reactivity	Human,
Applications	IHC
Clonality	Monoclonal;Recombinant
Immunogen	Recombinant human CD33 fragment
Abbre	CD33
Synonyms	CD33, SIGLEC-3, SIGLEC3, p67, CD33 molecule, gp67, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, CD33 molecule, p67, SIGLEC3
Swissprot	P20138
Cellular Localization	Membrane
Concentration	1 mg/mL
Buffer	PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Purification Method	Protein A purified
Research Areas	Immunology, Stem Cells
Clone No.	A170
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	Ice bag
background	Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules.

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Unconjugated