Recombinant Cdk9 Monoclonal Antibody (AN301276L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human pancreas |
| Dilution | IHC 1:200-1:1000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human Cdk9 protein |
| Abbre | Cdk9 |
| Synonyms | CDK, CTK, CDC2L, CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK, Cdk9 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm, Nucleus, PML body. Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the Cytoplasm, The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Cell Biology, Microbiology, Epigenetics and Nuclear Signaling, Immunology |
| Clone No. | 8B5 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | CDK9(cyclin dependent kinase 9) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. |
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Unconjugated
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