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Recombinant DcR1 Monoclonal Antibody - 1
  • Recombinant DcR1 Monoclonal Antibody - 1
  • Recombinant DcR1 Monoclonal Antibody - 2
  • Recombinant DcR1 Monoclonal Antibody - 3
All Size Price Qty
100μL $ 380.00
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50μL $ 249.00
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For research use only.

Verified Samples Verified Samples in WB: Raji,?Jurkat, 293T
Verified Samples in IF: Jurkat
Dilution WB 1:1000-1:2000,  IF 1:50
Isotype IgG, κ
Host Rabbit
Reactivity Human,  
Applications WB,  IF
Clonality Monoclonal;Recombinant
Immunogen Peptide. This information is proprietary to PTMab.
Abbre DcR1
Synonyms DCR,  UNQ,  PRO,  TRAILR,  TRAIL-R,  TNFRSF10C,  CD263,  DCR1,  DCR1-TNFR,  LIT,  TRAIL-R3,  TRAILR3,  TRID,  UNQ321,  PRO366,  DcR1,  TRID,  TNFRSF10c,  Antagonist Decoy Receptor for TRAIL/Apo-2L,  Decoy Receptor 1,  Decoy TRAIL Receptor Without Death Domain,  Lymphocyte Inhibitor of TRAIL,  TNF-Related Apoptosis-Inducing Ligand Receptor 3,  TRAIL Receptor 3,  TRAIL Receptor Without an Intracellular Domain,  Tumor Necrosis Factor Receptor Superfamily Member 10C
Swissprot
Calculated MW 27 kDa
Observed MW 27, 80-100 kDa
The actual band is not consistent with the expectation.

Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include:

1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein.

2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes.

3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1.

4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids).

5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers.

If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.

Cellular Localization Cell membrane
Concentration 1 mg/mL
Buffer PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Purification Method Protein A purified
Research Areas Cell Biology,  Immunology,  Cancer
Clone No. A716
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Ice bag
background The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems.The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand (TRAIL). They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.
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Unconjugated

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