Recombinant FGFR2 Monoclonal Antibody (AN301522L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human colon cancer, Mouse colon, Rat stomach |
| Dilution | IHC 1:50-1:100 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, Rat, Mouse |
| Applications | IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant human FGFR2 fragment |
| Abbre | FGFR2 |
| Synonyms | CFD, BFR, ECT, CEK, FGFR, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, FGFR2, KSAM, BEK, K-SAM |
| Swissprot | |
| Cellular Localization | Membrane, Secreted |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Cardiovascular, Signal Transduction, Neuroscience, Stem Cells, Cancer, Developmental Biology |
| Clone No. | A221 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. |
Other Clones
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Other Formats
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Unconjugated
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