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Recombinant Human Activin RIIA/ACVR2A Protein (His Tag) (PKSH033783)

All Size Price Qty
50μg $ 128.00
10μg $ 58.00
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For research use only.

Synonyms ACTR-IIA, ACTRII, ACTRIIA, ACVR2, ACVR2A, Activin Receptor Type IIA, Activin Receptor Type-2A
Species Human
Expression Host HEK293 Cells
Sequence Ala20-Pro134
Accession P27037
Calculated Molecular Weight 14.4 kDa
Observed Molecular Weight 28-38 kDa
Tag C-His
Bio-activity Not validated for activity
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, 10% Glycerol, 5% Trealose, pH7.4.
Reconstitution Not Applicable
Background Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
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