Recombinant Human Arylsulfatase A/ARSA Protein (His Tag) (PKSH032093)
For research use only.
| Synonyms | ARSA, ASA, Arylsulfatase A, Cerebroside-Sulfatase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg19-Ala507 |
| Accession | AAH14210.2 |
| Calculated Molecular Weight | 52.9 kDa |
| Observed Molecular Weight | 50-65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Form | Liquid |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, pH 8.0. |
| Background | Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down Cerebroside 3-Sulfate, a major constituent of the myelin sheet, into Cerebroside and Sulfate. The ARSA deficiency results in Metachromatic Leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. Recombinant Human ARSA corresponds to the ARSA mature peptide and has sulfatase activity. |
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