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Recombinant Human CD147/Basigin Protein (Fc Tag) (PKSH031785)

All Size Price Qty
100μg $ 680.00
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For research use only.

Synonyms 5F7, BSG, Basigin, CD147, Collagenase Stimulatory Factor, EMMPRIN, Extracellular Matrix Metalloproteinase Inducer, Leukocyte Activation Antigen M6, OK Blood Group Antigen, TCSF, Tumor Cell-Derived Collagenase Stimulatory Factor
Species Human
Expression Host HEK293 Cells
Sequence Met 1-His 205
Accession NP_940991.1
Calculated Molecular Weight 46.8 kDa
Observed Molecular Weight 58-65 kDa
Tag C-hFc
Bio-activity Not validated for activity
Purity > 97 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer); also known as Basigin (BSG); is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis; embryo implantation; neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells; and thereby promotes invasion; metastasis; growth and survival of malignant cells. Furthermore; CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently; CD147 displays increased expression in many cancers; and it has been previously demonstrated to participate in cancer metastasis and progression. Thus; CD147 and its antibody are used as an effective treatment for malignant cancers.
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