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Recombinant Human Chymotrypsin C Protein (His Tag) (PKSH033366)

All Size Price Qty
50μg $ 358.00
10μg $ 158.00
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For research use only.

Synonyms CLCR, CTRC, Caldecrin, Chymotrypsin-C
Species Human
Expression Host HEK293 Cells
Sequence Cys17-Leu268
Accession Q99895
Calculated Molecular Weight 29.0 kDa
Observed Molecular Weight 33-40 kDa
Tag C-His
Bio-activity Not validated for activity
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-Hcl, 150mM NaCl , pH7.5.
Reconstitution Not Applicable
Background Chymotrypsin C (CTRC) is a member of the peptidase S1 family. CTRC is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. CTRC has broad substrate specificity; but prefers tocleave on the carboxyl side of hydrophobic residues. CTRC is expressed primarily in the pancreas; and is secreted into the digestive tract. CTRC plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. It has been proposed that CTRC is a key regulator of digestive zymogen activation and is a physiological coactivator of digestive carboxypeptidases proCPA1 and proCPA2. The mutation of CTRC gene encodes the digestive enzyme CTRC contribute to the development of pancreatitis.
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