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Recombinant Human Complement Factor B/CFB Protein (His Tag) (PKSH032272)

All Size Price Qty
50μg $ 525.00
10μg $ 275.00
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For research use only.

Synonyms BF, BFD, C3/C5 Convertase, CFB, Complement Factor B, GBG, Glycine-Rich Beta Glycoprotein, PBF2, Properdin Factor B
Species Human
Expression Host HEK293 Cells
Sequence Thr 26-Leu764
Accession AAH04143.1
Calculated Molecular Weight 84.1 kDa
Observed Molecular Weight 90-120 kDa
Tag C-His
Bio-activity Not validated for activity
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution Not Applicable
Background Complement Factor B (CFB) belongs to the peptidase S1 family of enzymes. It is expressed by hepatocytes and macrophages and localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. CFB which is a component of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
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