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Recombinant Human CXCL7/NAP-2 Protein (PKSH032305)

All Size Price Qty
100μg $ 739.00
20μg $ 249.00
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For research use only.

Synonyms C-X-C Motif Chemokine 7, CTAP3, CXCL7, LDGF, Leukocyte-Derived Growth Factor, MDGFSmall-Inducible Cytokine B7, Macrophage-Derived Growth Factor, PBP, PPBP, Platelet Basic Protein, SCYB7, TGB1, THBGB1
Species Human
Expression Host E.coli
Sequence Ala59-Asp128
Accession P02775
Calculated Molecular Weight 8.4 kDa
Observed Molecular Weight 11 kDa
Tag N-His
Bio-activity Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2.The ED50 for this effect is <0.5 ng/mL.
Purity > 98 % as determined by reducing SDS-PAGE.
Endotoxin < 0.1 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Human Chemokine (C-X-C motif) Ligand 7 (CXCL7); also known as neutrophil activating peptide 2 (NAP-2); is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines; such as IL-8 and the GRO proteins; CXCL7 binds CXCR2; chemoattracts and activates neutrophils. CXCL7; Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG); are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII; βTG; and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains; these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
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