Recombinant Human Fcγ RIIB/CD32b Protein(Fc Tag) (PDMH100316)
For research use only.
| Synonyms | FCG, CDw, Fcgr, IGFR, FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2, CDw32, Fc-gamma-RIIb, FcRII-b, Low affinity immunoglobulin gamma Fc region receptor II-b, IgG Fc receptor II-b, Fc-gamma RII-b, CD32 antigen, Fc fragment of IgG, Fc gamma receptor IIB, Fc gamma RII, Fc gamma RIIB, FCG2B, Fc-gamma RII, FCRII, FcγRⅡ, IgG Fc receptor II beta, low affinity II, low affinity IIb, Low affinity immunoglobulin gamma Fc region receptor II, Ly-17, Lym 1, Lymphocyte antigen 17, receptor, receptor (CD32), receptor for, receptor for (CD32) |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Ala46-Pro217 |
| Accession | P31994 |
| Calculated Molecular Weight | 43.9 kDa |
| Observed Molecular Weight | 50 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors. |
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