Recombinant Human Galectin-12 protein(N-His) (PKSH034187)
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For research use only.
| Synonyms | GAL12, GRIP1, LGALS12 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser 2-Ser 336 |
| Accession | Q96DT0 |
| Calculated Molecular Weight | 38.4 kDa |
| Observed Molecular Weight | 38 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Galectin-12 (Gal-12) is a member of the tandem repeat-type galectin family, characterized by two carbohydrate recognition domains (CRD) connected by a linker region within a single peptide chain. The CRD mediates β-galactoside binding and is essential for interacting with the VPS13C protein. Gal-12 is expressed not only in adipose tissue but also in macrophages and other leukocytes. It participates in diverse biological processes, including cell cycle regulation, apoptosis, and differentiation. Notably, Gal-12 has been identified as a key driver of macrophage polarization toward the M1 phenotype, thereby promoting inflammation and reducing insulin sensitivity in adipocytes. Moreover, Gal-12 exhibits lactose-binding affinity and has been implicated in adipocyte apoptosis, suggesting a role in adipose tissue homeostasis and programmed cell death. These findings position Gal-12 as a potential therapeutic target for metabolic and inflammatory disorders. Animal-Free Galectin-12 Protein, Human (His), produced in E. coli with an N-terminal His tag, offers a recombinant tool for functional studies. This product is intended for cell culture applications, enabling researchers to investigate the molecular mechanisms of Gal-12 in immune regulation, adipocyte biology, and insulin resistance. |
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