Recombinant Human HO1 Protein(Trx Tag) (PDEH100474)
For research use only.
| Synonyms | HSP, heme oxygenase, heme oxygenase (decycling), bK286B, HO-1 HMOX, HMOX1, HMOX1D, HO-1, HSP32, bK286B10, 32 kD, D8Wsu38e, heat shock protein 32 kD, heat shock protein 32kD, Hemox, Hmox, HMOX 1, HO 1, HO-1 HMOX1, heme oxygenase (decycling) 1, heme oxygenase 1, heat shock protein, 32-kD, HO, HO1, bK286B10, heme oxygenase 1, HMOX1D, HO-1, HSP32 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Thr261 |
| Accession | P09601 |
| Calculated Molecular Weight | 48.7 kDa |
| Observed Molecular Weight | 48 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. |
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