Recombinant Human ICOSL Protein(His Tag) (PDMH100324)
For research use only.
| Synonyms | B7H, B7-H, B7 Homolog, B7-Like Protein Gl, B7-Related Protein, V-Set and Immunoglobulin Domain-Containing Protein, KIAA, VSIG, ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, B7 Homolog 2, B7-Like Protein Gl50, B7-Related Protein 1, ICOS Ligand, Protein Z39Ig, V-Set and Immunoglobulin Domain-Containing Protein 4, VSIG4, Z39IG, CRIg, KIAA0653, ICOSL, B7RP1, B7h, B7 H2, B7 homologue 2, B7 like protein Gl50, B7 related protein 1, B7RP 1, CD 275, CD275 antigen, GL 50, ICOS L, ICOS LG, Inducible T cell co stimulator ligand, Transmembrane protein B7 H2 ICOS ligand |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Met1~Ser258 |
| Accession | O75144 |
| Calculated Molecular Weight | 28.3 kDa |
| Observed Molecular Weight | 40-60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation. |
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