Recombinant Human IL-24 protein(His Tag) (PKSH034109)
For research use only.
| Synonyms | MDA, MOB, Melanoma Differentiation Association Protein, IL24, C49A, FISP, IL10B, MDA7, MOB5, ST16, MDA-7 (Melanoma Differentiation-Associated gene 7 protein), Melanoma Differentiation Association Protein 7, IL 24, IL 4 induced secreted protein, IL-24, interleukin 24, Interleukin-24, MDA-7, Melanocyte associated Mda 7, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16, Suppression of tumorigenicity 16 (melanoma differentiation), Suppression of tumorigenicity 16 protein |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gln 52-Leu 206 |
| Accession | Q13007 |
| Calculated Molecular Weight | 19.1 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to chemoattract BaF3 cells transfected with human IL-20R alpha and IL-20R beta. The ED50 for this effect is <120 pg/mL. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
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