Recombinant Human IL5RA/IL-5 Rα Protein (Fc Tag) (PKSH032652)
For research use only.
| Synonyms | CDw, HSIL5R, IL5RA, CD125, CDw125, HSIL5R3, IL5R, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, IL-5R&, alpha, CD125 antigen, IL5R, Interleukin 5 Receptor alpha, Interleukin 5 Receptor alpha chain, Interleukin 5 receptor alpha subunit, Interleukin 5 receptor subunit alpha, Interleukin 5 receptor type 3, MGC26560 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp21-Glu335 |
| Accession | Q01344 |
| Calculated Molecular Weight | 62.5 kDa |
| Observed Molecular Weight | 70-85 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Interleukin-5 Receptor alpha (IL-5Rα; CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 Rα consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif; a 20 aa transmembrane segment; and a 58 aa cytoplasmic domain. Within the ECD; human IL-5Rα shares 71% aa sequence identity with mouse and rat IL-5 Rα. Alternate splicing of human IL-5 Rα generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 Rα and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 Rα binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5Rα followed by eosinophilic differentiation and activation. |
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