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Recombinant Human KIR2DL4/CD158D Protein (His Tag) (PKSH032675)

All Size Price Qty
50μg $ 128.00
10μg $ 58.00
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For research use only.

Synonyms CD158 Antigen-Like Family Member D, CD158D, CD158d, G9P, KIR-103AS, KIR103AS, KIR2DL4, Killer Cell Immunoglobulin-Like Receptor 2DL4, Killer Cell Inhibitory Receptor 103AS, MHC Class I NK Cell Receptor KIR103AS
Species Human
Expression Host HEK293 Cells
Sequence Trp22-His242
Accession ADY38409.1
Calculated Molecular Weight 25.3 kDa
Observed Molecular Weight 30-40 kDa
Tag C-His
Bio-activity Not validated for activity
Purity > 80 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
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