Recombinant Human LAG3/CD223 Protein (His Tag) (PKSH033596)
For research use only.
Synonyms | CD223, LAG-3, LAG3, Lymphocyte activation gene 3 protein, Protein FDC |
Species | Human |
Expression Host | HEK293 Cells |
Sequence | Leu23-Leu450 |
Accession | P18627 |
Calculated Molecular Weight | 47.2 kDa |
Observed Molecular Weight | 60-80 kDa |
Tag | C-His |
Bio-activity | Immobilized Human LAG-3-His at 5μg/ml (100 μl/well) can bind Human FGL1-mFc.The ED50 of Recombinant Human FGL1-mFc is 30-90 ng/ml. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, 2mM EDTA, pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
Reconstitution | Please refer to the printed manual for detailed information. |
Background | Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4. |
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