Recombinant Human LMCD1/Dyxin Protein (His Tag) (PKSH032706)

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All	Size	Price	Qty
	50μg	$ 288.00	- +
	10μg	$ 128.00	- +

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Synonyms	Dyxin, LIM and cysteine-rich domains protein 1, LMCD1
Species	Human
Expression Host	E.coli
Sequence	Met 1-Ser365
Accession	Q9NZU5
Calculated Molecular Weight	44.0 kDa
Observed Molecular Weight	45 kDa
Tag	N-His & C-His
Bio-activity	Not validated for activity
Form	Liquid
Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0.
Background	LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

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