Recombinant Human OCLN Protein(GST Tag) (PDEH101112)
For research use only.
| Synonyms | PPP1R, PTORCH, OCLN, BLCPMG, PPP1R115, PTORCH1, occludin |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Arg269-Thr522 |
| Accession | Q16625 |
| Calculated Molecular Weight | 53.8 kDa |
| Observed Molecular Weight | 58 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | OCLN (Occludin) is a Protein Coding gene. This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. It belongs to the ELL/occludin family. OCLN is an important component of the tight junction complex, providing apical intercellular connections between adjacent cells in endothelial and epithelial tissue. OCLN, an integral tight junction protein, is one of the key factors for HCV entry into cells. OCLN, a key receptor for HCV, is a candidate target of miR-122; the most abundant hepatic micro RNA. Over-expression of miR-122 can decrease HCV entry into hepatocytes through down-regulation of OCLN. Diseases associated with OCLN include Pseudo-Torch Syndrome 1 and Torch Syndrome. |
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