Recombinant Human PYM1/WIBG Protein (His Tag) (PKSH032857)

For research use only.
Synonyms | PYM, Partner of Y14 and Mago, Protein Wibg Homolog, WIBG |
Species | Human |
Expression Host | E.coli |
Sequence | Met 1-Leu204 |
Accession | Q9BRP8 |
Calculated Molecular Weight | 23.7 kDa |
Observed Molecular Weight | 30 kDa |
Tag | C-His |
Bio-activity | Not validated for activity |
Purity | > 80 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, pH 8.0. |
Reconstitution | Not Applicable |
Background | Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC). EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs, is a positional landmarker for the intron exon structure of genes, and directs post-transcriptional processes in the cytoplasm, for instance mRNA export, nonsense-mediated mRNA decay or translation. WIBG is a cytoplasmic RNA-binding protein, it can be excluded from nucleus by Crm1. WIBG as a cooperateing partner of Mago-14, relates with Mago-14 by its N-terminal domain. |
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