Recombinant Human RCN2 (C-6His) (PKSH034035)
For research use only.
| Synonyms | E6BP, ERC55, RCN2, Reticulocalbin-2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly23-Leu317 |
| Accession | Q14257 |
| Calculated Molecular Weight | 35.6 kDa |
| Observed Molecular Weight | 50-55 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, 1mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
| Background | Reticulocalbin-2 (RCN2, also named as ERC-55), is a 55-kDa Ca2+-binding protein containing six EF-hands, which was identified to be localized in endoplasmic reticulum. RCN2 is belonging to Reticulocalbin (RCN) family, the family members could play oncogenic roles in human malignancies and facilitate tumor cell proliferation and metastasis. Recently, studies on RCN2 functions mainly focused on its role in differentiation and endocrine regulation in mouse. Another study has suggested that RCN2 could be a potential tumor-associated antigen for mammary cancer immunological prevention. Up to now, the experimental evidence uncovering the role of RCN2 in cancer is very limited. |
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