Recombinant Human SGSH Protein (His Tag) (PKSH032823)
For research use only.
| Synonyms | HSS, N-Sulphoglucosamine Sulphohydrolase, SGSH, Sulfoglucosamine Sulfamidase, Sulphamidase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg21-Leu502 |
| Accession | P51688 |
| Calculated Molecular Weight | 55.7 kDa |
| Observed Molecular Weight | 63 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
| Background | N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. SGSH deficiency is result in mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations. |
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