Recombinant Human SH2D1A/SAP Protein (His Tag) (PKSH031236)
For research use only.
| Synonyms | DSHP, Duncan Disease SH2-Protein, EBVS, IMD5, LYP, MTCP1, SAP/SH2D1A, SH2 Domain-Containing Protein 1A, SH2D1A, SLAM-Associated Protein, Signaling Lymphocytic Activation Molecule-Associated Protein, T-Cell Signal Transduction Molecule SAP, XLP, XLPD, XLPD1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Pro 2-Lys 97 |
| Accession | NP_002342.1 |
| Calculated Molecular Weight | 15.6 kDa |
| Observed Molecular Weight | 14 kDa |
| Tag | N-His |
| Bio-activity | Measured by its ability to bind recombinant human SLAMF1, human SLAMF6, mouse SLAMF6, mouse CD84 in functional ELISA. |
| Form | Lyophilized powder |
| Purity | > 94 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.5, 20% glycerol Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome. |
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