Recombinant Human STAT3 Protein(GST Tag) (PDEH100640)
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For research use only.
| Synonyms | 1110034C02Rik, Acute Phase Response Factor, Acute-Phase Response Factor, ADMIO, ADMIO1, APRF, AW109958, DNA binding protein APRF, FLJ20882, HIES, MGC16063, Signal Transducer and Activator of Transcription, Signal Transducer and Activator of Transcription 3, Signal transducer and activator of transcription 3 (acute phase response factor), STAT, STAT 3, STAT3 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala2-Ser219 |
| Accession | P40763 |
| Calculated Molecular Weight | 49.8 kDa |
| Observed Molecular Weight | 50 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 85% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. |
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