Recombinant Human STAT3 Protein(GST Tag) (PDEH100640)
For research use only.
| Synonyms | STAT, Signal Transducer and Activator of Transcription, ADMIO, ADMIO1, APRF, HIES, STAT3, Acute-Phase Response Factor, Signal Transducer and Activator of Transcription 3, 1110034C02Rik, Acute Phase Response Factor, AW109958, DNA binding protein APRF, FLJ20882, MGC16063, Signal transducer and activator of transcription 3 (acute phase response factor), STAT 3 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala2-Ser219 |
| Accession | P40763 |
| Calculated Molecular Weight | 49.8 kDa |
| Observed Molecular Weight | 50 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
| Purity | > 85% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
| Background | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. |
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