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Recombinant Human THOP1 Protein (His Tag) (PKSH033105)

All Size Price Qty
50μg $ 358.00
10μg $ 158.00
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For research use only.

Synonyms Endopeptidase 24.15, MP78, THOP1, Thimet Oligopeptidase
Species Human
Expression Host E.coli
Sequence Lys2-Cys689
Accession P52888
Calculated Molecular Weight 80.0 kDa
Observed Molecular Weight 85 kDa
Tag C-His
Bio-activity Not validated for activity
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 50% Glycerol, pH 7.4.
Reconstitution Not Applicable
Background Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
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