Recombinant Human TLK1/PKU-beta Protein (His & GST Tag) (PKSH030339)
For research use only.
| Synonyms | KIAA0137, PKU-beta |
| Species | Human |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Met 1-Tyr 766 |
| Accession | Q9UKI8-1 |
| Calculated Molecular Weight | 114 kDa |
| Observed Molecular Weight | 125 kDa |
| Tag | N-His-GST |
| Bio-activity | The specific activity was determined to be 1. 6 nmol/min/mg using Histone H3 protein as substrate. |
| Purity | > 88 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol |
| Reconstitution | Not Applicable |
| Background | The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. |
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