Recombinant Human UCHL1/PGP9.5 Protein (His Tag) (PKSH033175)

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All	Size	Price	Qty
	50μg	$ 128.00	- +
	10μg	$ 58.00	- +

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Synonyms	HEL-117, NDGOA, Neuron Cytoplasmic Protein 9.5, PARK5, PGP 9.5, PGP9.5, UCH-L1, UCHL1, Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1, Ubiquitin Thioesterase L1, Uch-L1
Species	Human
Expression Host	E.coli
Sequence	Met 1-Ala223
Accession	P09936
Calculated Molecular Weight	25.9 kDa
Observed Molecular Weight	26 kDa
Tag	C-His
Bio-activity	Not validated for activity
Form	Liquid
Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 250mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.
Background	Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) belongs to the Peptidase C12 family. UCHL1 is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. UCHL1 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. UCHL1 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity.

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