Recombinant Human VEGF-B/VEGFB Protein (Fc Tag) (PKSH033474)
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For research use only.
| Synonyms | Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Pro22-Ala207 |
| Accession | P49765 |
| Calculated Molecular Weight | 45.7 kDa |
| Observed Molecular Weight | 40&60 kDa |
| Tag | N-Fc |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20 mM Glycine, 6% Sucrose, 5% Mannitol, 0.05% Tween80, pH3.0. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | VEGFB, as known as VRF, is a member of the VEGF family of growth factors that share structural and functional similarity. By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. The two VEGF-B isoforms have identical amino-terminal cysteine-knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. VEGF-B167 and a proteolytically processed form of VEGF-B186 also bind neuropilin-1, a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance. |
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