Recombinant LDLR Monoclonal Antibody (AN301402L)
For research use only.
| Verified Samples | Verified Samples in IHC: Mouse liver |
| Dilution | IHC 1:1000-1:4000 |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human LDLR protein |
| Abbre | LDLR |
| Synonyms | LDLCQ, LDLR, FH, FHC, LDLCQ2, low-density lipoprotein receptor, Familial Hypercholesterolemia, LDL R, LDL receptor, FHC, LDLCQ2, low-density lipoprotein receptor |
| Swissprot | |
| Cellular Localization | Cell membrane, Single-pass type I membrane protein, Membrane, clathrin-coated pit, Golgi apparatus, Early endosome, Late endosome, Lysosome, Rapidly endocytosed upon ligand binding. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Cardiovascular, Signal Transduction, Cancer, Metabolism |
| Clone No. | 11B5 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
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Other Formats
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Unconjugated
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