Recombinant MORF4L2 Monoclonal Antibody (AN302049L)
For research use only.
| Verified Samples |
Verified Samples in WB: K562,?HeLa, U-87 MG Verified Samples in IHC: Human breast cancer, Human colon cancer |
| Dilution | WB 1:2000-1:5000, IHC 1:100 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Peptide. This information is proprietary to PTMab. |
| Abbre | MORF4L2 |
| Synonyms | KIAA, Protein MSL3, Mortality Factor 4-Like Protein, MORFL, MORF4L, MORF4L2, MORFL2, MRGX, MORF-Related Gene X Protein, Mortality Factor 4-Like Protein 2, Protein MSL3-2, Transcription Factor-Like Protein MRGX, KIAA0026, KIAA0026, MO4L2, MORF related gene X protein, Mortality factor 4 like protein 2, MSL3 2 protein, Transcription factor like protein MRGX |
| Swissprot | |
| Calculated MW | 32 kDa |
| Observed MW |
32 kDa
Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Cellular Localization | Nucleus |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Epigenetics and Nuclear Signaling, Metabolism, Cancer |
| Clone No. | A769 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The MRGX protein is a component of the NuA4 histone acetyltransferase complex. It alters the interaction between nucleosomes and DNA byacetylating histones H4 and H2A, thereby facilitating the interaction between modified histones and other proteins that positively regulatetranscription. It plays an important role in selective gene transcription activation. In addition, the MRGX protein is also a component of theMSIN3A complex, where it inhibits transcription by deacetylating histones. |
Other Clones
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Unconjugated
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