Recombinant Mouse 4-1BB/TNFRSF9 Protein (aa 24-187, Fc Tag) (PKSM041199)
For research use only.
| Synonyms | 4-1BB, A930040I11Rik, AA408498, AI325004, CDw137, Cd137, ILA, Ly63, Secreted CD137 antigen, Tnfrsf9 , Tumor necrosis factor receptor superfamily member 9 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Val24-Leu187 |
| Accession | P20334 |
| Calculated Molecular Weight | 44.7 kDa |
| Observed Molecular Weight | 60-70 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
| Background | Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. |
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