Recombinant Mouse APRIL/TNFSF13 Protein(Fc Tag) (PDMM100178)
For research use only.
| Synonyms | TALL, TRDL, TNFSF, A proliferation-inducing ligand, CD256, TALL-2, TRDL-1, April, Tnfsf13, TALL-2, TNFSF13 |
| Species | Mouse |
| Expression Host | Mammalian |
| Sequence | Ala96-Leu241 |
| Accession | Q9D777 |
| Calculated Molecular Weight | 40.9 kDa |
| Observed Molecular Weight | 42 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF17/BCMA. TNFSF13 is lowly expressed in normal tissues, but is elevated in several types of tumors and transformed cell lines. It is important for B cell development. TNFSF13 may also play a role in T-independent type II antigen responses and T cell survival, and induce proliferation/survival of non lymphoid cells. It exists as a functional homotrimer. It can bind to two cell surface receptors, BCMA and TACI, which it shares with BAFF to exert downstream T-and B-cell regulatory effects. TNFSF13 also has been demonstrated to bind to proteoglycans on the cell surface. |
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