Recombinant Mouse CD30 Ligand/TNFSF8 Protein(Fc Tag) (PDMM100135)
For research use only.
| Synonyms | TNFSF, Cd30l, Cd30lg, Tnfsf8, TNFSF8, CD153, CD30 ligand, Tumor necrosis factor ligand superfamily member 8 |
| Species | Mouse |
| Expression Host | Mammalian |
| Sequence | Gln68-Asp239 |
| Accession | P32972 |
| Calculated Molecular Weight | 43.8 kDa |
| Observed Molecular Weight | 55-65 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | CD30 ligand (CD30L) , also known as CD153 and TNFSF8 , is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily , and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells , stimulated monocyte-macrophages , granulocytes , eosinophils , and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines , and mediates pleiotropic biologic effects including cell proliferation , activation , differentiation , as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas , particularly Hodgkin disease , large cell anaplastic lymphomas and Burkitt lymphomas , and is also involved in activation and functioning of the T cell-dependent immune response. Thus , CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies , autoimmune and inflammatory diseases.全称 |
Other Clones
{{antibodyDetailsPage.numTotal}} Results
-
{{item.title}}
Citations ({{item.publications_count}}) Manual MSDS
Cat.No.：{{item.cat}}
{{index}} {{goods_show_value}}
Other Formats
{{formatDetailsPage.numTotal}} Results
-
{{item.title}}
Citations ({{item.publications_count}}) Manual MSDS
Cat.No.：{{item.cat}}
{{index}} {{goods_show_value}}
-
IF：{{item.impact}}
Journal：{{item.journal}} ({{item.year}})
DOI：{{item.doi}}Reactivity：{{item.species}}
Sample Type：{{item.organization}}
-
Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}}
