Recombinant Mouse Chromogranin-A/Chga protein (His Tag) (PDEM100227)
For research use only.
| Synonyms | CHG A, CMGA, CgA, Chga, Chromogranin A, Chromogranin A parathyroid secretory protein 1, Chromogranin A precursor, ChromograninA, ER-37, Pancreastatin, Parastatin, Parathyroid secr, beta Granin, betagranin (N-terminal fragment of chromogranin A), catestatin, chromofungin |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Leu19-Met150 |
| Accession | P26339 |
| Calculated Molecular Weight | 14.4 KDa |
| Observed Molecular Weight | 15-20 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation . Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress . |
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