Recombinant Mouse Fas Ligand/TNFSF6 Protein(Fc Tag) (PDMM100156)
For research use only.
| Synonyms | Tnfsf, Apt1lg, IL-27p, IL-27, ALPS1B, APTL, CD178, IL, IL27-A, IL-27-A, IL-27p28, Apt1lg1, Cd95l, Fasl, gld, Tnfsf6, Faslg, Fas, CD95L, APO-1, TNFSF6, TNFRSF6, CD95L, IL- |
| Species | Mouse |
| Expression Host | Mammalian |
| Sequence | Pro132-Leu279 |
| Accession | P41047 |
| Calculated Molecular Weight | 41.2 kDa |
| Observed Molecular Weight | 55-60 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Fas Ligand , also known as FASLG and CD95L , is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance , in the antigen-stimulated suicide of mature T-cells , or both. |
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