Recombinant Mouse IL-23A Protein(Fc Tag) (PDMM100097)
For research use only.
| Synonyms | IL 23, IL 23 A, IL 23 subunit alpha, IL 23A, IL 23p19, IL-23 subunit alpha, IL-23-A, IL-23p19, IL12B, IL23, Il23a, IL23A_HUMAN, IL23P19, interleukin 12B, Interleukin 23 alpha subunit p19, Interleukin 23 p19 subunit, interleukin 23 subunit alpha, interleukin 23 subunit p19, interleukin six, G CSF related factor, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, JKA3 induced upon T cell activation, MGC79388, P19, SGRF |
| Species | Mouse |
| Expression Host | Mammalian |
| Sequence | Val22-Ala196 |
| Accession | Q9EQ14 |
| Calculated Molecular Weight | 44.1 kDa |
| Observed Molecular Weight | 40-50 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease. |
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