Recombinant Mouse IL-36RA protein(His Tag) (PKSM041482)
For research use only.
| Synonyms | EBI, Interleukin, Il1f, Il1h, Il1hy, EBI3, EBV-induced gene 3 protein, Epstein-Barr virus-in duced gene 3 protein, IL-27-A, IL-27B, IL-30, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, Interleukin-30, p28, Fil1d, Il1f5, Il1h3, Il1hy1, IL36RN |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Met 2-Asp 156 |
| Accession | Q9QYY1 |
| Calculated Molecular Weight | 17.8 kDa |
| Observed Molecular Weight | 17-25 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to inhibit IL-36 gamma-induced IL-6 secretion in 3T3 cells. The ED50 for this effect is <2 μg/mL. |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity. |
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