Recombinant Mouse Il6RA/CD126 protein (His Tag) (PDMM100024)
For research use only.
| Synonyms | MGC, Membrane glycoprotein, IL-6R-Alpha, IL6RQ, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, MGC30256, CD126, gp80, IL6Q, IL-6R, IL-6R 1, IL-6R subunit alpha, IL-6R-1, Il6r, Il6ra, IL-6R&, alpha, IL-6RA, interleukin 6 receptor, Interleukin-6 receptor |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Glu357 |
| Accession | P22272 |
| Calculated Molecular Weight | 39.2 kDa |
| Observed Molecular Weight | 58 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer. |
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