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Recombinant Mouse Interleukin-2/IL-2 Protein (PKSM040308)

All Size Price Qty
100μg $ 520.00
20μg $ 198.00
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For research use only.

Synonyms POIL, OTTHUMP, Aldesleukin, IL 2, Interleukin 2, Involved in regulation of T cell clonal expansion, Lymphokine, OTTHUMP00000164090, POIL2, T Cell Growth Factor, T-cell growth facter, Interleukin-2, IL2, TCGF, T-cell growth factor, Il-2
Species Mouse
Expression Host E.coli
Sequence Ala 21-Gln 169
Accession P04351
Calculated Molecular Weight 18.2 kDa
Observed Molecular Weight 18 kDa
Tag C-His
Bio-activity Measure by its ability to induce CTLL-2 cells proliferation. The ED50 for this effect is <0.3 ng/mL. The specific activity of recombinant mouse IL-2 is approximately >3 x 106 IU/mg.
Purity > 98 % as determined by reducing SDS-PAGE.
Endotoxin < 0.1 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to the IL-2 family. Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.
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Biotinylated

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