Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag) (PKSM040305)
For research use only.
| Synonyms | AW259666, pp60c-src |
| Species | Mouse |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Met 1-Leu 535 |
| Accession | NP_001020566.111 |
| Calculated Molecular Weight | 87.7 kDa |
| Observed Molecular Weight | 80 kDa |
| Tag | N-His-GST |
| Bio-activity | The specific activity was determined to be > 80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate. |
| Form | Liquid |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0 |
| Background | Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity. |
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