Recombinant MRE11 Monoclonal Antibody (AN301268L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Human cervical carcinoma |
| Dilution | IHC 1:200-1:1000, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human MRE11 protein |
| Abbre | MRE11 |
| Synonyms | AT like disease, Ataxia telangiectasia disorder like, ATLD, DNA recombination and repair protein, Double strand break repair protein MRE11A, Double-strand break repair protein MRE11A, endo/exonuclease Mre11, HNGS, HNGS1, meiotic recombination (S. cerevisiae) 11 homolog A, Meiotic recombination 11 homolog 1, Meiotic recombination 11 homolog A, meiotic recombination 11 homolog A (S. cerevisiae), MmMRE11A, MRE, Mre 11, MRE 11a, MRE 11b, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11 homolog double strand break repair nuclease, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11A, MRE11B, OTTHUMP00000236830, OTTHUMP00000236831, OTTHUMP00000236832, OTTHUMP00000236833 |
| Swissprot | |
| Cellular Localization | Nucleus, Chromosome, telomere, Chromosome, Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Epigenetics and Nuclear Signaling |
| Clone | C110891 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
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