Recombinant MYH7 Monoclonal Antibody (AN301987L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Human cardiac muscle, Human skeletal muscle, Human colon(Negative tissue), Mouse skeletal muscle, Rat skeletal muscle |
| Dilution | IHC 1:1000-1:2000 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, Rat, Mouse |
| Applications | IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Peptide. This information is proprietary to PTMab. |
| Abbre | MYH7 |
| Synonyms | CMH, MPD, MYH, myosin, MYH7, CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin-7, PVALB |
| Swissprot | |
| Cellular Localization | Cytoplasm, myofibril |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Signal Transduction, Stem Cells, Cardiovascular, Developmental Biology, Immunology |
| Clone No. | A707 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regulate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa,IIb, and IIc, respectively. While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATPhydrolysis, their cellular functions do not appear to be redundant and they have different subcellular distributions. The carboxy-terminal taildomain of myosin II is important in isoform-specific subcellular localization. Research studies have shown that phosphorylation of myosin IIa at Ser1943 contributes to the regulation of breast cancer cell migration. |
Other Clones
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Other Formats
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Unconjugated
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